DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE alcohol 701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1

701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1

Berishvili

Product Name Thalidomide-5'-O-C6-OH Synonyms CAS Number 2493431-00-6 Related CAS Molecular Formula C19H22N2O6 Molecular Weight 374

626 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCCCCN)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

461 Purity (HPLC) >= 95% Solubility DMSO

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE alcohol 701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing