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We have demonstrated that both ZOT 5 -1-Me and ZOT 5 -1-Et induced DNA damage, including SSBs and ALS, in the U-87 MG cell line (Fig

In cancer, TST dysregulation affects redox balance and H 2 S metabolism, potentially promoting tumor progression and suggesting TST's role as a biomarker and therapeutic target in oncology

They discovered a unique and specific manganese-binding site within the cytosolic cavity of the transporter that is formed by residues Asp40, Asn127, Asp248, and Ser252, and showed that the conserved residue Asp40 is critical, as its mutation abolishes Mn 2+ binding and transport

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