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Concurrently, depression affects approximately 300 million people globally, with years lived with disability accounting for 37.3% of all mental disorders, rendering it a leading cause of disability (GBD 2019 Mental Disorders Collaborators, 2022)

48 Furthermore, different subsets of macrophages present distinct metabolic functions

doi: 10.1146/annurev.cellbio.24.110707.175235 137 SuredaFCopaniABrunoVKnpfelTMeltzgerGNicolettiF

Lipid metabolism is associated with developmental epigenetic programming

Nutrients 15:1620 De Felice A, Greco A, Calamandrei G, Minghetti L (2016) Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism