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Astrocytes induce blood-brain barrier properties in endothelial cells

Results: In the RADIcAL2 cohort, 38% of patients had no rejection, while 62% had either indeterminate (21%) or T-cell mediated rejection (41%)

10.1016/j.bbagen.2013.01.005 91

For decades, these cells were viewed primarily through the lens of neuroinflammation and neuronal damage, particularly due to their well-documented release of pro-inflammatory cytokines, including TNF-, IL-1, and IL-6 in conditions like AD and PD [124, 453455]