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Uncontrolled explosive release of drugs from nanocarriers can often result in acute toxicity issues

NAD+ IV Therapy involves a slow intravenous infusion that usually takes longer and is often chosen for deeper, extended sessions

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By bilaterally injecting lentiviral vectors carrying siRNA targeting GSK-3 into the hippocampal dentate gyrus region to modulate GSK-3 activity, the study found that IF promoted neuronal differentiation and maturation in the dentate gyrus and improved the known dysfunction in 3xTg-AD mice

doi: 10.3389/fendo.2025.1592683 Received 12 March 2025 Accepted 02 June 2025 Published 24 June 2025 Volume 16 - 2025 Edited by Lynda Bourebaba, Wroclaw University of Environmental and Life Sciences, Poland Reviewed by Klaus-Dieter Schlter, University of Giessen, Germany Nawel Adjeroud, University of Bjaa, Algeria Updates Copyright 2025 Bou Matar, Zhra, Nassar, Altemyatt, Naureen, Abotouk, Elahi and Aljada