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Both matter but neither should drive the decision on its own

Beyond detoxification, GSH is essential for immune system function, DNA synthesis and repair, protein and enzyme activation, and the regeneration of other antioxidants such as vitamins C and E

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Mutants that are impaired in glutathione biosynthesis exhibited a stronger growth inhibition than WT seedlings when exposed to AITC, independent of whether the mutation was present in the first or second enzyme of glutathione biosynthesis (Figs 2 and 3)

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis