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Description

Culturing HSCs in conditioned medium from M1 macrophages upregulated the expression of fibrosis-related genes (CTGF, TIMP1) and YAP-regulated genes (ANKRD1, CYR61)

Combining glutamine-targeted treatments with oncogene inhibitors may create synthetic lethality

Under physiological conditions, estrogen precisely regulates spermatogenesis and maintains the integrity of the blood-testis barrier (BTB) via its receptors (ER, ER, GPER) and epigenetic modifications (151153)

The investigators followed the patients for 51 months

Therefore, it has been theorized that inhibition of xCT activities could promote Glu to replenish the TCA cycle intermediates, which could promote ROS production (102) ( Figure 4 )