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The two basic parameters are clearance , the measure of the ability of the body to eliminate the drug

whilst B12 toxicity is rare, unnecessarily high doses offer no additional benefit Be aware of interactions: metformin and acid-suppressing drugs can reduce B12 levels

Genetic Risk Factors: Thrombophilia (example: Factor V Leiden mutation, prothrombin gene mutation, protein C deficiency, protein S deficiency, hyperhomocysteinemia) (13)

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However, a 2013 meta-analysis found no significant negative effects linked to to the peptide when tested in randomized, double-blind, placebo-controlled studies, whether given intravenously or orally (6)