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FIGURE 4 Role of p38/MAPK Activation in Lipopolysaccharide-Induced Human Dermal Fibroblast Migration and Proliferation and Microtubule Depolymerization We explored the role of p38/MAPK in the regulation of HDF migration and proliferation and MT depolymerization

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The present study used 1 g L -1 of wPE containing 1204 117 microplastic/m 3 and this concentration was used as the sublethal concentration ( At the end of each exposure period, about twelve fish (6 male and 6 female) from each tank were dissected to isolate the internal organs such as the gut and liver for biochemical and mRNA expression study

The compound is referenced across a wide spectrum of preclinical models, with most literature focusing on three thematic areas: Skin biology: Studies on dermal fibroblast behaviour, collagen and elastin synthesis pathways, and extracellular matrix remodelling Gene expression modulation: Research examining the compounds reported activity across thousands of genes in genome-wide expression studies Antioxidant & copper transport: Models exploring its role as a physiological copper carrier and free radical interaction The 50mg and 100mg vial formats make GHK-Cu particularly suitable for extended research protocols where higher peptide volumes are required compared with the typical 510mg formats used for other research compounds