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Furthermore, the three primary variants of ApoE have recently been revealed to undergo varying degrees of sialylation, with ApoE2 exhibiting the most abundant sialic acid modification, whereas ApoE4 is the least sialylated

Fc tags can be expensive to produce and purify since they require mammalian cell expression systems and affinity resins

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Notably, these studies found that simple endothelial cell cultures did not show the same angiogenic response, suggesting that BPC-157 may act as a context-dependent regulator of vascular signaling rather than a direct angiogenic stimulus

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