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Smoke production remained good but a small a tunnel in the center of the stick was likely responsible for the profile weakness

Long-term epidemiological studies of alternative non-combustible nicotine-containing products are ideal for the evaluation of product use and clinical disease outcomes

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Observational studies have shown clinical improvement in response to corticosteroids, but it is unclear whether clinical improvement was due to steroids since the natural history of untreated EVALI is not known [15, 37, 40]