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doi: 10.1016/j.bbagen.2021.129979 14 WymanSSimpsonRJMcKieATSharpPA

While considerable data have been accumulated to support the important role for GSH in aging, little information is available regarding the mechanisms responsible for its depletion during aging

A 2025 systematic review covers 36 studies: 35 preclinical and one clinical study with 12 patients. New blood-vessel formation, nitric oxide signaling, and FAK-paxillin repair-cell migration are well characterized