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This mechanism not only reshapes the immunosuppressive state of the tumor microenvironment but also provides key targets for breaking immune tolerance and improving the efficacy of immunotherapy

Medical physics 50(1):323-329, 2023

Studies on gut microbiota transplantation in animals confirmed that dysbiosis may increase thyroid autoimmunity susceptibility [179]

Salmain M, Gaschard M, Baroud M, Lepeltier E, Jaouen G, Passirani C, Vessieres A (2023) Thioredoxin reductase and organometallic complexes: a pivotal system to tackle multidrug resistant tumors

However, rutin is capable of creating adducts with histidine residues in the active site of tyrosinase, which leads to tyrosinase inhibition and stops the production of melanin [74]