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In a recent work, the group of von Zastrow showed that after being recruited by the phosphorylated MOR, arrestin 3 acts as a scaffold, promoting ubiquitination of two lysyl residues in the first intracellular loop by the ubiquitin ligase Smurf2 (Henry et al., DPDPE also enables arrestin-mediated endocytosis of DOR as shown by the partial reduction of internalization when arrestins 2 or 3 are selectively inhibited (Zhang et al., 2005)

doi: 10.1371/journal.ppat.1009220 23 GengR.DaiM.WangY.LiH

Calibration was obtained using hydrogen peroxide (0.220 M)

Certificates of Analysis (COAs) are available for verification of quality

Sontakke P et al