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Description

These oxygen free radicals lead to lipid, protein, and DNA damage inside cells, which leads to structural and functional abnormalities in periodontal tissues and escalates disease progression

As an inhibitor of histone deacetylases (HDACs), butyrate facilitates acetylation at FOXP3 gene promoter regions on histone H3 (83).SCFAs also exert an influence on dendritic cell development and inflammatory cytokine production, thereby modulating the function of intestinal macrophages (84)