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Despite targeting both isoforms of GLS1, when CB-839 was tested against a panel of breast cancer cells, its effectiveness was limited to triple-negative breast cancer cells, which have elevated GAC expression and activity compared to receptor-positive cells (Gross et al, 2014)

Drug Metab Rev 38 , 651675 (2006)

Is Phentermine a GLP-1 Medication

doi:10.3109/00498259409043238 Furfaro AL, Nitti M, Marengo B, Domenicotti C, Cottalasso D, Marinari UM, Pronzato MA, Traverso N (2012) Impaired synthesis contributes to diabetes-induced decrease in liver glutathione

Furthermore, in vitro studies that aim to simulate oral drug exposure should verify whether the applied flavonoid concentrations are achievable through in vivo metabolism following oral intake