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PMID: 108 ShinS-JShimG-YMoonS-HKimY-JKimH-JOhSet al

After absorption, iron ions are oxidized by ceruloplasmin in the blood to trivalent iron ions, which then bind to transferrin receptor and enter the cells in the form of pinocytosis for hematopoietic cells

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NF-kB, nuclear factor kappa B

SP can target the macrophages to accelerate the protein degradation of Kelch-like ECH-associated protein 1 (KEAP1) via microtubule-associated protein 1 light chain 3 (LC3)-mediated autophagy and ubiquitin-mediated proteasome degradation