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Proper single-color and negative controls were used in every experiment to optimize gating

Recent studies have also shown that the inflammatory response of macrophages can be attenuated by inhibiting succinic acid (63, 64)

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Therapeutic potential of the insulin/IGF-1/PI3K/AKT/mTOR pathway in modulating aging and cancer As discussed above, the signaling cascades mediated by the insulin/IGF-1/PI3K/AKT/mTOR pathway exhibit synergistic effects in modulating both aging and cancer