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Outside of SLE, microglial SR-G1 has been proposed as a therapeutic target to reduce neuroinflammation (312), and LGALS3BP may be a therapeutic target for its roles in angiogenesis and tumor progression (313)

These findings align with global analyses from Europe, North America, and Asia reporting similar population-level increases in vitamin B12 deficiency, where prevalence ranges from 5 to 20% depending on age, diet, and socioeconomic status

LacCer pathway induce a reactive pro-inflammatory state of astrocytes (112), and via CCL2 and GMCSF production induces recruitment and activation of microglia and macrophages

It modulates cardiac protection via regulation of EphA2 tyrosine phosphorylation