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Comment: Commenters submitted an abundance of information on coordinated care and referral services within OTP settings, including the types of service provider entities in the community OTPs interact with, examples of operational processes in OTP settings related to these activities, the types of referral services OTPs refer patients to, potential resource costs associated with rendering coordinated care and referral services, current public and private funding mechanisms for these activities, and existing coding that may appropriately describe these activities in OTP settings

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Key finding: NNMT positioned as a master metabolic regulator at the intersection of NAD+ salvage, one-carbon metabolism, and epigenetic control