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Researchers examine how this endogenous peptide affects sleep latency, sleep stage distribution, cortisol/corticosterone levels, and stress-induced sleep disturbances in experimental systems focused on sleep neuroscience and stress physiology

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Accordingly, increased serum markers of intestinal barrier damage and epithelial apoptosis, such as intestinal fatty acid-binding protein (I-FABP), and cytokeratin 18 have been found in patients with T1D [59]

One interpretation that is often cited regarding such case reports is that these were examples of a dysmyelination resulting from a defined gene defect or an acquired/sporadic condition, with coincidental MS (Pfeffer et al., 2013