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They induced cell cycle arrest at the G2/M phase and increased the number of apoptotic cells

While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019

Importantly, significant reductions were observed across all three major FAST components: VCTE, CAP and AST

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Nishiyama et al, 2010), which is coupled to DNA replication through linking cohesin acetyltransferases ESCO1/2 with several replisome components including MCM, PCNA and CRL4 MMS22L (Ivanov et al, 2018