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These might be a better option for people with increased nutrient needs or those at a greater risk of deficiency, including individuals with medical conditions that affect absorption

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(PMC) A separate metabolism-focused paper reviewing human trial history makes a similar point: early signals of weight loss were not consistently reproduced in later studies, particularly when intensive diet/exercise protocols were included

Vitamin B-12 is administered for those who have an actual deficiency or persons who have had cyanide poisoning (as an antidote), says Fatima Cody Stanford, M.D., obesity medicine physician at Massachusetts General Hospital