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Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

Okutsu M, Call JA, Lira VA et al (2014) Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure

2 Introduction Excessive alcohol intake is a leading cause of preventable death in the United States

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While the exposure to an early-life HFHS diet did not have significant lasting effects on the content of dopamine, its metabolites DOPAC and HVA, or its precursor L-DOPA in the striatum of adult female or male mice, adult female mice showed some effects on its metabolism, including an increased L-DOPA/dopamine ratio (ANOVA: F 2, 14 = 9.31, p = 0.003, = 0.57