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ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig

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The roles of HO-1 discussed in this table are in the context of promoting ferroptosis

Chronic altitude sickness CMS The prevalence of CMS varies by altitude, lung disease, sex, age, sleep apnea, obesity, and genetic factors