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Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus

Abstract Background The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke

omitted systematic evaluation of RGD-modified nanoparticles targeting stability under dynamic pathological conditions (e.g., fibrosis or chronic inflammation), limiting generalizability of their therapeutic strategy ( 5.5 Quercetin Quercetin, a flavonol ubiquitously distributed in the plant kingdom (chemical formula C 15 H 10 O 7 , molecular weight 302.24 Da), predominantly occurs in nature as glycosidic forms such as rutin, liberating free quercetin upon acid hydrolysis or enzymatic conversion

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Furthermore, erastin treatment enhances autophagosome formation and the expression of TFR1 and NCOA4 while downregulating GPX4 and FTH1 (Fig