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Results Disalicylic acid and naphthoic acid derivatives as potent inhibitors of human ME2 On the basis of site-directed mutagenesis of the dimer or tetramer interfaces, the fumarate-binding site, and the exo site, we previously reported that 4,4-Methylene-bis(3-hydroxy-2-naphthoic acid), also known as embonic acid (EA), may act as an allosteric inhibitor of ME2 41