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This is because these methods allow the optimization of several design and development processes (4) In this regard, some recent examples of these developments about the solubility prediction of drugs are described in the literature as follows: in neat water (9), in simulated gastrointestinal fluids (10), in organic solvents (11) and in mixed solvents (12-14)

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moreover it is still unclear whether GIP has direct, insulin independent, metabolic effects on adipose tissue

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