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Funding This work was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) to AB, and by a NASA Space Biology Postdoctoral Fellowship (80NSSC19K0426) to SAN

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In addition, a systematic umbrella review, which examined the major areas of research regarding the hypothesis that serotonin is deficient during depression, found no evidence that brain deficiency or low activity of the neurotransmitter is at the root of the psychiatric disorder [10]

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Finally, the possibility arises that meningococcus may use the olfactory and trigeminal nerves to reach the CNS directly from the nose, bypassing the bloodstream, but this intriguing hypothesis requires further support