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L-serine can also be generated through the folate cycle via serine hydroxymethyltransferase (SHMT) 1 localized in the cytoplasm (Fig

Symptoms of Sneddon syndrome include: A rash resembling fishnet patterns or snake skin, known as livedo reticularis when appearing on the limbs and fading with warmth, or livedo racemosa when persistent on the trunk and buttocks

B12 plays a direct role in synthesizing and maintaining myelin, the protective coating that allows nerve fibers to transmit signals efficiently

The appropriate route and dose depend on the clinical scenario

Finally, integration of creatine-centered diagnostics and therapeutics with multi-omics data, computational modeling, and digital health monitoring could overcome existing translational barriers