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Cell-based assays and animal studies also report changes in gene expression linked to anabolic signaling, lipid metabolism, and cellular repair processes

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The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells

Likewise, further research will be required to understand which of those E3 ligases provides a tangible differentiation from CRBN and VHL, the two E3 ligases that are harnessed by clinically approved or evaluated MGDs and PROTACs