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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

Adipocyte signaling and lipid oxidation models

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As well, an underlying assumption of this analysis is that patients will comply with oral supplementation

These oral supplements pass through the digestive system like food and release the vitamin to restore healthy blood levels