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This combination may be one of the potential treatments used in preventing prostate diseases and provide a novel, supportive therapy for prostate hyperplasia [52]

Comprehensively, the combined application of metformin with other treatment modalities in cancer treatment may yield superior therapeutic outcomes compared with standalone approaches

Nitrogen oxides (NOXs) provide a source of accumulation of ROS in erastin-induced iron sickness, and it has been reported to modulate the sensitivity of tumor cells to erastin (Dixon et al., 2012)

In addition, Treg cells likely control atherosclerotic lesion inflammation resolution as recent studies demonstrated that Treg cells regulate efferocytosis in atherosclerotic lesions by secreting IL-13 to stimulate macrophage production of IL-10 to induce Vav-1 activation of Rac1 and increased efferocytosis (215)

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