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& Hickey, M

Complex interactions with these pathways consist of positive feedback mechanisms for both mutual expansions (Figure 5) (Strollo et al., 2013

These include pro-angiogenic molecules: growth factors, including vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha transcription factor (HIF-1), platelet-derived growth factor (PDGF-B), transforming growth factor (TGF-), fibroblast growth factor, placental growth factor (PlGF), interleukins, as well as anti-angiogenic factors: angiostatin, endostatin, thrombospondins 1 and 2 (Qiang et al