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Changes in the coupling efficiency of receptors to signal transduction pathways and receptor internalization can account for desensitizationand the development of pharmacodynamic

In our experimental design, we established a D-galactose-induced aging mouse model and injected the experimental group mice with FOXO4-DRI for 1 month, while the control group was injected with equal amounts of PBS

Male rats were used over female rats in order to eliminate any skewed data that may result from hormonal fluctuations related to the rats reproductive cycles