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Additionally, PKM2 seems to play an important role in EC function and angiogenesis as silencing of PKM2 resulted in decreased sprouting (Gmez-Escudero et al., 2019), but also in reduced VE-cadherin expression resulting in destabilization of the cellular junctions (Gmez-Escudero et al., 2019)

Because of this, higher doses, typically 5001,000 mg per day, are often required to see measurable benefits (NIH)

Vitamin C also helps in: Iron absorption, prevents iron deficiency anemia