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Cyclic dimeric guanosine monophosphate (c-di-GMP) is an ubiquitous second messenger found in many prokaryotes such as Mycobacterium tuberculosis, Vibrio cholerae , or Salmonella enterica that regulates a wide span of physiological processes including bacterial protein secretion, multicellular behaviour, virulence, motility, and cell development and differentiation [112,113]

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