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In contrast to the oxidized variants, the UT and DTT-treated samples contained reduced, slowly migrating GSAAT ( Figure 3B )

As microarray analysis indicated upregulation of inflammatory genes shortly after injection of 6-OHDA [237], it may be possible that BBB leakage is first triggered by neuroinflammation and then driven by dopaminergic cell loss [236]

The B vitamins also play a major role in glutathione synthesis and the metabolism of homocysteine 22