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Two antisense oligonucleotides that specifically interact with the mRNAs of the protein kinase C-, responsible for tyrosinase phosphorylation and thus its activation [115], decreased tyrosinase activity in cultured melanocytes and reduced hand pigmentation in volunteers after applying a care product containing these synthetic agents [116]

A: The benefits of glutathione are usually seen after at least three weeks of treatment

These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

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