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Key points Graves disease is an autoimmune condition that can involve the thyroid exclusively or can be associated with extrathyroidal manifestations, of which Graves orbitopathy is the most common

Prolonged use of certain creams (e.g., hydroquinone) can be harmful

Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2by miR-96-5p

1 Platinum complexes which entered clinical trials While most of the platinum drugs have to be administered intravenously, Satraplatin (8) was the first orally applicable platinum agent under clinical investigation (Fig