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Numerous studies have shown that senescence of alveolar type 2 (AT2) cells in IPF promotes fibrogenesis through a TP53-dependent mechanism, which significantly contributes to the progression of the disease

In those who require acetylcysteine, 2 hours before completion of infusion check ALT/AST and paracetamol concentration (in those with high initial paracetamol concentrations greater than double the 150mg at 4 h nomogram line) to determine need for ongoing acetylcysteine

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recently demonstrated that mtROS drives CD8 + T-cell senescencea dysfunctional state distinct from exhaustion [129]