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In controlled clinical trials, NRT increases smoking cessation rates at 1-year follow-up by approximately 5060% over placebo [11], but its real-world effectiveness is lower [12, 13]

The WHOs Framework Convention on Tobacco Control (FCTC) offers a comprehensive legal framework and guidelines for implementing tobacco control policies worldwide [39]

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Cancer and the total deaths due to smoking have fallen sharply in men in high-income countries but will rise globally unless current smokers, most of whom live in low- and middle-income countries, stop smoking before or during middle age