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523,535 AChE/GSK-3 inhibitors 48 536 and 49, 537 developed through a pharmacophore linkage strategy, exhibited promising results by significantly inhibiting tau hyperphosphorylation and ameliorating cognitive disorders in scopolamine-treated ICR mice

About this article Cite this article Arunim, Dagar, M., Solanki, M

One of its underlying mechanisms is the diabetes-associated myocardial remodelling and myocardial hypertrophy (98)

While these drugs show potential in reducing amyloid plaque burden, they come with risks such as amyloid-related imaging abnormalities with edema (ARIA-E), which can pose significant challenges to their widespread clinical use (Kurkinen, 2023

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