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1 Introduction Epilepsy is a common chronic neurological disorder, with approximately 50 million people living with epilepsy worldwide and 5 million new cases each year

For instance, efficacy and BBB permeabilization properties of ADCs, the influence of drug-to-antibody ratio (DAR) on payload concentration and their diffusion with target tissue/cell selectivity, linker design, and potential of payload smartly bypassing multidrug efflux transporters (e.g

AC: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

Screening efforts to explore the pharmacopeia for antimicrobial compounds also identified auranofin and ebselen for antimicrobial properties that appear to also target TrxR (Figure 2)