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10.1016/j.neuron.2004.06.021 Neuron 128 PayneB

During the lecture Pauling, now age 65, expressed a wish to live long enough to see realized all the scientific advancements on the horizon

As a consequence, the hydrolysis of extracellular ATP and accumulation of adenosine are favored, and signaling via adenosine receptors promotes deoxygenation of sickle hemoglobin and in turn (HbS) polymerization and RBC sickling