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Shannon & Simpson Diversity and the Chao1 Index were calculated through the vegan package in RStudio

The necessity for appropriate comparators and the patient-specific nuances of TE interventions pose challenges in conducting traditional randomized controlled trials (RCTs) or extrapolating findings across patients

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Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)