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60,61 In the CNS, they play a major role in dynamic signaling such as clearing waste, tuning brain blood flow, regulating vascular function, ion hemostasis and balancing neuroimmune responses

Observed concentrations of levosimendan and its metabolites were significantly lower in neonates/infants than in adults

Herein, we mainly discuss the specific events involved in BCBM

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These alterations occur in particular in the central DNA-binding domain (DBD) and are classified as mutations affecting DNA contact, as a result of changes of critical amino acids indispensable for p53 binding, such as R248Q (rs11540652), R273H (rs28934576), and R282W (rs28934574), or conformational mutations that lead to either a loss of protein structure or altered conformation, such as R175H (rs28934578), Y220C (rs121912666), G245S (rs28934575), and R249S (rs28934571) (Zhou et al