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In most patients, the pain resolves with 1 or 2 injections, however, 3 injections may be required to achieve complete benefit

As part of multistage tumourigenesis, angiogenic switch arises from an imbalance between pro- and inhibitors of angiogenesis activity and level

For GSH assay, cells were treated in Earles balanced salt solution (EBSS), supplemented with 25 mM glucose, 4 mM glutamine, 1 X MEM vitamin solution (Life technologies, CA, USA), 0.22% wt/vol NaHCO 3 , 1 mM sodium pyruvate, 0.2% BSA, 25 mM HEPES, 100 U/ml penicillin and 100 g/ml streptomycin in the presence or absence of 1 X MEM amino acid solution (Gibco, CA, USA) with or without 100 M cystine

Notably, this inhibitory effect has no impact on the apoptosis of astrocytes (Garca-Nogales et al., 2003)

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