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[,,,] Under pathological conditions, the five zang-fu systems also affect each other, and thus, participates in the pathogenesis or reversion of human diseases

Vps39 interacts with Tom40 to establish one of two functionally distinct vacuole-mitochondria contact sites

[84] demonstrated that in colorectal cancer, suppression of the MondoATXNIP axis promotes glucose uptake and glycolysis, leading to the induction of highly glycolytic, Th17-like Tregs

[71] also reported that the activation of STAT3 enhanced the FoxO-dependent expression of inhibitor of B (IB) proteins which induced the accumulation of NF-B complexes into cytoplasm, inhibiting the pro-inflammatory NF-B-dependent gene expression

McKenna et al 2014)