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Consistency in timing within a cycle matters more than the specific time chosen, as it helps isolate effects from other variables and maintains steady circadian signaling

This subtype demonstrates elevated OXPHOS activity and increased mitochondrial gene expression, reflecting a reliance on mitochondrial metabolism rather than glycolysis for energy production (83)

ROS promote epithelial-mesenchymal transition (EMT), migration, invasion (e.g., by regulating MMPs), and survival of circulating tumor cells from anoikis and oxidative stress within the blood circulation [32]

The fact that the cells grow in clusters only mimics the natural properties that tumor cells exhibit

The burden of headache in China: Validation of diagnostic questionnaire for a population-based survey